Title of article :
Synthesis of alkyl 2-(bromomethyl)aziridine-2-carboxylates and alkyl 3-bromoazetidine-3-carboxylates as amino acid building blocks
Author/Authors :
Mangelinckx، نويسنده , , Sven and ?ukauskait?، نويسنده , , Asta and Buinauskait?، نويسنده , , Vida and ?a?kus، نويسنده , , Algirdas and De Kimpe، نويسنده , , Norbert، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
A short synthesis of alkyl 2-(bromomethyl)aziridine-2-carboxylates and alkyl 3-bromoazetidine-3-carboxylates was developed involving amination, bromination, and base-induced cyclization of alkyl 2-(bromomethyl)acrylates. These new small ring azaheterocyclic α- and β-amino acid derivatives are promising synthons as demonstrated by their transformation to 2-(aminomethyl)aziridine-2-carboxylates and 3-aminoazetidine-3-carboxylates.
Keywords :
2-(bromomethyl)aziridines , Aziridine-2-carboxylates , Azetidine-3-carboxylates , ring closure , 3-Bromoazetidines
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
