Title of article
The role of a Lewis acid in the Nenitzescu indole synthesis
Author/Authors
Velezheva، نويسنده , , Valeriya S. and Sokolov، نويسنده , , Andrey I. and Kornienko، نويسنده , , Albert G. and Lyssenko، نويسنده , , Konstantin A. and Nelyubina، نويسنده , , Yulia V. and Godovikov، نويسنده , , Ivan A. and Peregudov، نويسنده , , Alexander S. and Mironov، نويسنده , , Andrey F.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
7106
To page
7109
Abstract
A highly efficient Lewis acid-catalyzed method for the Nenitzescu synthesis of 5-hydroxyindoles with a range of substituents at N-1 and C-3 and symmetric 5,5′-dihydroxydiindoles has been developed. The amount of the catalyst (10–100 mol %) required depended on the nature of the enaminone component. It has been shown that Lewis acid plays a role in enaminone component activation through an enamine-ZnC12 complex followed by its deprotonation.
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1861875
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