Author/Authors :
O’Neil، نويسنده , , Ian A. and Hitchin، نويسنده , , James and Bhamra، نويسنده , , Inder and Chorlton، نويسنده , , Alan P. and Tapolczay، نويسنده , , David J.، نويسنده ,
Abstract :
Lithiation of 3-methoxymethyl quinuclidine N-oxide occurs regioselectively to generate the 2-lithio 3-methoxymethyl derivative which can be trapped out with non-enolisable electrophiles to give 2,3-disubstituted quinuclidine N-oxide derivatives in good yield.
