Title of article
Directed lithiation on the quinuclidine ring system: the synthesis of 2,3-difunctionalised quinuclidines
Author/Authors
O’Neil، نويسنده , , Ian A. and Hitchin، نويسنده , , James and Bhamra، نويسنده , , Inder and Chorlton، نويسنده , , Alan P. and Tapolczay، نويسنده , , David J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
7416
To page
7418
Abstract
Lithiation of 3-methoxymethyl quinuclidine N-oxide occurs regioselectively to generate the 2-lithio 3-methoxymethyl derivative which can be trapped out with non-enolisable electrophiles to give 2,3-disubstituted quinuclidine N-oxide derivatives in good yield.
Keywords
amine oxide , lithiation , Quinuclidine
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1862094
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