Author/Authors :
Pellizzaro، نويسنده , , Leonardo and Tatibouët، نويسنده , , Arnaud and Fabris، نويسنده , , Fabrizio and Rollin، نويسنده , , Patrick and Lucchi، نويسنده , , Ottorino De Lucchi، نويسنده ,
Abstract :
Diphenylphoshinoylethyne reacts with diols under basic conditions to produce cycloacetalic phosphine oxides. The reaction appears to be general and particularly effective with carbohydrate derivatives. The 2-(diphenylphoshinoyl)ethylidene (DPE) acetals produced are stable in acidic media while they can be cleaved under reductive and/or basic conditions: base-catalyzed transacetalization is a method of choice for their mild and effective deprotection.
Keywords :
Cyclic acetals , protective groups , Ethynylphosphine oxide , carbohydrates
