Author/Authors :
Shinonaga، نويسنده , , Hideki and Kawamura، نويسنده , , Yoji and Ikeda، نويسنده , , Akiko and Aoki، نويسنده , , Mari and Sakai، نويسنده , , Noriyoshi and Fujimoto، نويسنده , , Natsuko and Kawashima، نويسنده , , Akira، نويسنده ,
Abstract :
WNT-5A, a secretory glycoprotein, is related to the proliferation of dermal papilla cells. While searching for an inhibitor of WNT-5A expression, we identified an active compound, radicicol (1), and isolated four unique analogues, pochonins G–J (2–5), from a culture broth of the fungus Pochonia chlamydosporia TF-0480. Structural elucidation of 2–5 and their biological activities against WNT-5A are described.
