Author/Authors :
Llauger، نويسنده , , Laura and Bergami، نويسنده , , Costanza and Kinzel، نويسنده , , Olaf D. and Lillini، نويسنده , , Samuele and Pescatore، نويسنده , , Giovanna and Torrisi، نويسنده , , Caterina and Jones، نويسنده , , Philip، نويسنده ,
Abstract :
Functionalized fused heteroaryl pyrazinones were built up through a novel DBU-catalyzed intramolecular hydroamination reaction of aryl(prop-2-yn-1-yl)-1H-heteroaryl-2-carboxamides. The nucleophilic addition afforded three isomers; two with an exo-cyclic double bond [cis (Z), trans (E)], and a third one with an endo-cyclic double bond. After the carboxamide deprotection, isomerization of the mixture under acidic conditions resulted in a unique isomer.
Keywords :
Intramolecular hydroamination , Pyrrolopyrazinones , Fused-heteroaryl pyrazinones , DBU-mediated cyclisation , isomerisation
