Author/Authors :
Nakatsuka، نويسنده , , Hiroshi and Shimokawa، نويسنده , , Kenichiro and Miwa، نويسنده , , Ryoka and Yamada، نويسنده , , Kaoru and Uemura، نويسنده , , Daisuke، نويسنده ,
Abstract :
The first total synthesis and biological evaluation of the naturally occurring cyclic heptapeptide rhizonin A are described. The synthesis includes solution-phase peptide synthesis and the preparation of NMe-3-(3-furyl)alanine (NMe-FurAla), a unique component of rhizonin A, which was prepared in chiral form via Barton-MacCombie deoxygenation as a key step. The bioactivity was assessed using 3T3–L1 murine adipocytes.
