Author/Authors :
Okuyama، نويسنده , , Yuko and Nakano، نويسنده , , Hiroto and Watanabe، نويسنده , , Yuki and Makabe، نويسنده , , Mika and Takeshita، نويسنده , , Mitsuhiro and Uwai، نويسنده , , Koji and Kabuto، نويسنده , , Chizuko and Kwon، نويسنده , , Eunsang، نويسنده ,
Abstract :
4-Hydroxy-prolinamide alcohol with different noncoordination sites as a molecule showed excellent asymmetric catalytic activity in both the Michael reaction (up to 98% ee) and the direct aldol reaction (up to >99% ee), and the catalyzing reactions with high enantioselectivity are supported by a DFT theoretical study of their transition state.
Keywords :
Michael reaction , aldol reaction , DFT calculations , organocatalyst , 4-Hydroxy-prolinamide alcohol
