Signaling cascades initiated by TSLP-mediated signals in different cell types

Thymic stromal lymphopoietin (TSLP) has been well characterized as a consequence of its ability to modulate allergic and neoplastic diseases. However, downstream signaling mediated by TSLP varies significantly between the cell type and species examined. Since this observation is often overlooked and in some cases ignored, this review aims to consolidate the molecular pathways activated by TSLP receptors expressed by various human and mouse cell types.