Title of article
MAOS protocols for the general synthesis and lead optimization of 3,6-disubstituted-[1,2,4]triazolo[4,3-b]pyridazines
Author/Authors
Aldrich، نويسنده , , Leslie N. and Lebois، نويسنده , , Evan P. and Michelle Lewis، نويسنده , , L. and Nalywajko، نويسنده , , Natalia T. and Niswender، نويسنده , , Colleen M. and David Weaver، نويسنده , , C. and Jeffrey Conn، نويسنده , , P. and Lindsley، نويسنده , , Craig W.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
212
To page
215
Abstract
General, high-yielding MAOS protocols for the expedient synthesis of functionalized 3,6-disubstituted-[1,2,4]triazolo[4,3-b]pyridazines are described amenable to an iterative analog library synthesis strategy for the lead optimization of an M1 antagonist screening hit. Optimized compounds proved to be highly selective M1 antagonists.
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1862260
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