Title of article :
Th17 cells in type 1 diabetes
Author/Authors :
Shao، نويسنده , , Shiying and He، نويسنده , , Fan and Yang، نويسنده , , Yan and Yuan، نويسنده , , Gang and Zhang، نويسنده , , Muxun and Yu، نويسنده , , Xuefeng، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2012
Pages :
6
From page :
16
To page :
21
Abstract :
T1D is an autoimmune disorder, which involves the CD4+ as well as CD8+ T-cell–mediated destruction of β cells. Recently, another population of T cells (Th17) is found to be involved in T1D pathology. This review will discuss the characteristics of Th17 cells and the mechanism of Th17-mediated T1D development. Th17 cell expansion is unstrained under T1D condition. Certain Treg cells are defective in T1D and lose the control of Th17 expansion. In addition, the altered function of APCs and a subset of monocytes which spontaneously secrete IL-1β and IL-6 in T1D determine the abnormal expansion of Th17 as well. The pathogenic Th17 cells can cause the imbalance between Teff and Treg cells. Conversion from Th17 to Th1 phenotype and Th17 stimulated CTL responses may play an accessory role in T1D as well. Due to the effects of Th17 on T1D, therapeutic strategies designed to inhibit these cells are applicable and the positive effects are obvious. Taken together, Th17 may exert essential effects on the development of T1D. Identification of the underlying mechanism may inspire new viewpoints for the therapy of this disease.
Keywords :
T helper 17 cell , Regulatory T cell , Autoimmunity , Effector T cell , Type 1 diabetes
Journal title :
Cellular Immunology
Serial Year :
2012
Journal title :
Cellular Immunology
Record number :
1862278
Link To Document :
بازگشت