Author/Authors :
Wan ، نويسنده , , Zehong and Yan، نويسنده , , Hongxing and Hall، نويسنده , , Ralph F. and Lin، نويسنده , , Xichen and Livia، نويسنده , , Stefano and Respondek، نويسنده , , Tomasz and Widdowson، نويسنده , , Katherine L. and Zhu، نويسنده , , Chongjie and Callahan، نويسنده , , James F.، نويسنده ,
Abstract :
Chemoselectivity of chlorine versus methylthio (–SCH3), methylsulfinyl (–SOCH3), or methylsulfonyl [–S(O)2CH3] in either functionalization or substitution of pyridopyrimidinone and pyrimidopyrimidinone was studied. Utilization to prepare final targets for accelerated SAR studies via two-dimensional array syntheses has been demonstrated in both systems.
