Author/Authors :
Baati، نويسنده , , Rachid and Mioskowski، نويسنده , , Charles and Kashinath، نويسنده , , Dhurke and Kodepelly، نويسنده , , Sanjeevarao and Lu، نويسنده , , Biao and Falck، نويسنده , , J.R.، نويسنده ,
Abstract :
Methyl (Z)-α-methoxyacrylates are generated in good yields by a mild, stereospecific two-carbon homologation of a wide variety of aldehydes utilizing commercial methyl 2,2-dichloro-2-methoxyacetate and CrCl2 under Barbier conditions at room temperature. A rational mechanism based upon a Reformatsky-type addition pathway or an in situ generated (E)-trioxo-chromium vinylidene carbenoid is proposed.
