Author/Authors :
Vasdev، نويسنده , , Neil and van Oosten، نويسنده , , Erik M. and Stephenson، نويسنده , , Karin A. and Zadikian، نويسنده , , Nonik and Yudin، نويسنده , , Andrei K. and Lough، نويسنده , , Alan J. and Houle، نويسنده , , Sylvain and Wilson، نويسنده , , Alan A.، نويسنده ,
Abstract :
A highly regioselective method was developed for ring-opening benzyloxycarbonyl (Cbz)-protected 2-methylaziridine with [18F]-labelled fluoride. Following catalytic hydrogenation, 1-[18F]fluoro-2-propanamine ([18F]1) and 2-[18F]fluoro-1-propanamine ([18F]2) were prepared as the major and minor products, respectively (85:15), and were characterized following acylation with benzyl chloride. This methodology is applicable towards the generation of new [18F]-labelled amines for incorporation into radiopharmaceuticals.
Keywords :
aziridine , Fluorine-18 , ring-opening , Fluoroisopropylamine , PET , 1-Fluoro-2-propanamine , 2-Fluoro-1-propanamine
