Title of article :
An abnormal phenotype of lung Vγ9Vδ2 T cells impairs their responsiveness in tuberculosis patients
Author/Authors :
El Daker، نويسنده , , Sary and Sacchi، نويسنده , , Alessandra and Montesano، نويسنده , , Carla and Altieri، نويسنده , , Alfonso Maria and Galluccio، نويسنده , , Giovanni and Colizzi، نويسنده , , Vittorio and Martini، نويسنده , , Federico and Martino، نويسنده , , Angelo، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
Pages :
7
From page :
106
To page :
112
Abstract :
Antigen-specific γδ T cells represent an early innate defense known to play an important role in anti-mycobacterial immunity. We have investigated the immune functions of Vγ9Vδ2 T cells from Broncho-Alveolar lavages (BAC) samples of active TB patients. We observed that BAC Vγ9Vδ2 T cells presented a strong down-modulation of CD3 expression compared with Vγ9Vδ2 T cells from peripheral blood. Furthermore, Vγ9Vδ2 T cells mainly showed a central memory phenotype, expressed high levels of NK inhibitory receptors and TEMRA cells showed low expression of CD16 compared to circulating Vγ9Vδ2 T cells. Interestingly, the ability of BAC Vγ9Vδ2 T cells to respond to antigen stimulation was dramatically reduced, differently from blood counterpart. These observations indicate that γδ T cell functions are specifically impaired in situ by active TB, suggesting that the alveolar ambient during tuberculosis may affect resident γδ T cells in comparison to circulating cells.
Keywords :
Mycobacterium , ?? T cells , Primary infection , Lung
Journal title :
Cellular Immunology
Serial Year :
2013
Journal title :
Cellular Immunology
Record number :
1862501
Link To Document :
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