Facile synthesis of 1,1-[2H2]-2-methylaminoethane-1-sulfonic acid as a substrate for taurine α ketoglutarate dioxygenase (TauD)

Taurine α-ketoglutarate dioxygenase (TauD) is an archetypal α-ketoglutarate-dependent non-heme iron oxygenase. Here, we report a practical five-step synthetic route to 1,1-dideutero-2-methylaminoethanesulfonic acid hydrochloride, a useful alternative substrate for the characterization of deuterium kinetic isotope effects on TauD.