Author/Authors :
Xu، نويسنده , , Zhou and Wu، نويسنده , , Nan and Ding، نويسنده , , Zhenhua and Wang، نويسنده , , Ting and Mao، نويسنده , , Jincheng and Zhang، نويسنده , , Yawen، نويسنده ,
Abstract :
The easily prepared chiral tertiary amino alcohol 1a was found to catalyze the reaction of alkynylzinc reagents with various aldehydes to generate chiral propargylic alcohols with moderate-to-good enantioselectivities. The mechanism of the reaction is also discussed in this Letter. A novel theoretical computation of those evaluated ligands was introduced which may supply valuable experience to help designing new chiral ligands.
