Practical cleavage of trifluoroacetamides with p-toluensulfonic acid
Author/Authors :
Spencer، نويسنده , , Cierra and Balsells، نويسنده , , Jaume and Li، نويسنده , , Hongmei، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Pages :
3
From page :
1010
To page :
1012
Abstract :
A practical and efficient cleavage of trifluoroacetamides with p-TsOH·H2O has been developed. The deprotected amines are isolated directly from the reaction mixture as tosylate salts. This method can be applied to both secondary and tertiary trifluoroacetamides in good isolated yields.
