Author/Authors :
Rosen، نويسنده , , Mark D. and Simon، نويسنده , , Zahna M. and Tarantino، نويسنده , , Kyle T. and Zhao، نويسنده , , Lucy X. and Rabinowitz، نويسنده , , Michael H.، نويسنده ,
Abstract :
A general method for the synthesis of benzimidazole-4-sulfonamides is described. This methodology employs commercially available benzothiadiazole-4-sulfonyl chloride as a benzimidazole equivalent. Reaction with a variety of amines followed by highly chemoselective reductive desulfurization gives intermediate 1,2-phenylenediamines, which may then react with aryl, heteroaryl, and alkyl aldehydes to provide substituted benzimidazole sulfonamides.
