Author/Authors :
Okuma، نويسنده , , Kosuke and Ono، نويسنده , , Akira M. and Tsuchiya، نويسنده , , Seiji and Oba، نويسنده , , Makoto and Nishiyama، نويسنده , , Kozaburo and Kainosho، نويسنده , , Masatsune and Terauchi، نويسنده , , Tsutomu، نويسنده ,
Abstract :
We have developed a synthetic route for (2S,3R)- and (2S,3S)-[2-13C;3-2H] glutamic acids with high enantioselectivity. The key reactions in this synthesis are the asymmetric reduction of the 2,3-didehydroornithine derivative using the (S,S)-Et-DuPHOS-Rh catalyst and the oxidation of the δ-position by ruthenium catalysis.
