Author/Authors :
Jacob، نويسنده , , Raquel G. and Dutra، نويسنده , , Luiz G. and Radatz، نويسنده , , Cلtia S. and Mendes، نويسنده , , Samuel R. and Perin، نويسنده , , Gelson and Lenardمo، نويسنده , , Eder J.، نويسنده ,
Abstract :
A general and easy method for the synthesis of several 1,2-disubstituted benzimidazoles using SiO2/ZnCl2 and solvent-free conditions is described. This efficient and improved method furnishes selectively and in good yields the corresponding 1,2-bis(organyl)-benzimidazoles starting from o-phenylenediamine and aromatic or aliphatic aldehydes. The catalytic system was re-used up three times and the use of focused microwaves accelerates the reaction.
