Author/Authors :
Yakushiji، نويسنده , , Fumika and Maddaluno، نويسنده , , Jacques and Yoshida، نويسنده , , Masahiro and Shishido، نويسنده , , Kozo، نويسنده ,
Abstract :
The highly diastereoselective construction of substituted tetrahydropyrans, a common core segment (C3–C10) of the thiomarinols and the pseudomonic acid antibiotics, has been accomplished using the intramolecular oxy-Michael reaction under both basic and high-pressure conditions followed by regio- and stereoselective epoxide opening with acetylide.
