Author/Authors :
Calo، نويسنده , , Frederick M. Richardson، نويسنده , , Jeffery and White، نويسنده , , Andrew J.P and Barrett، نويسنده , , Anthony G.M.، نويسنده ,
Abstract :
An enantioselective formal total synthesis of (−)-trachyspic acid was carried out using, as key steps, an asymmetric aldol reaction of a chiral oxazolidinone and a diastereoselective alkylation of a chiral 1,3-dioxolan-2-one. The key lactone 3 was synthesized in five steps starting from dioxolanone 9.
