Author/Authors :
Pathirana، نويسنده , , Charles and Shukla، نويسنده , , Rajesh and Castoro، نويسنده , , John and Weaver، نويسنده , , Douglas and Byrne، نويسنده , , Liam and Pennarun-Thomas، نويسنده , , Gaelle and Palaniswamy، نويسنده , , Venkatapuram، نويسنده ,
Abstract :
A minor side product in a manufacturing batch of the intermediate 4 was observed and separated. The minor side product 5 was purified by preparative HPLC and its structure was determined by the analysis of comprehensive NMR and MS data. The structure of 5 reveals that its mechanism of formation includes a rare conversion of a pyridine moiety to a pyrrole.
Keywords :
pyridine , pyrrole , Ring contraction , Ring opening , Side product , epoxide
