Author/Authors :
Paradowska، نويسنده , , Joanna and Rogozi?ska، نويسنده , , Maria and Mlynarski، نويسنده , , Jacek، نويسنده ,
Abstract :
The tertiary amine-catalyzed direct asymmetric aldol reaction of hydroxyacetone with a variety of aromatic aldehydes is developed. Using 5–10 mol % of quinidine as catalyst, the direct aldol condensation products were obtained in reasonable yields and with asymmetric induction (up to 47% ee). The present approach is extended to asymmetric organocatalytic strategies for the preparation of 1,2-diols.
