Title of article
Approaches to the synthesis of CF2-analogues of 2-deoxy-2-aminoglycosides
Author/Authors
Poulain، نويسنده , , Florent and Leclerc، نويسنده , , Eric and Quirion، نويسنده , , Jean-Charles، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
1803
To page
1805
Abstract
The preparation of a fluorinated C-glycosidic analogue of a 2-deoxy-2-acetamido-d-altrose is described. The synthetic sequence involves the addition of a difluoroenoxysilane to a d-glucal, an epoxidation of the resulting unsaturated CF2-glycoside and a ring-opening reaction with TMSN3. An Overman rearrangement of the unsaturated intermediate is also described.
Keywords
aminoglycosides , glycomimetics , fluorine , epoxidation
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1863197
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