Author/Authors :
McKay، نويسنده , , Craig S. and Kennedy، نويسنده , , David C. and Pezacki، نويسنده , , John Paul، نويسنده ,
Abstract :
Micelle-promoted, copper-catalyzed multicomponent Kinugasa reactions were studied in aqueous media. Reactions were performed in a ‘single pot’ for a series of in situ generated C,N-diphenylnitrones with Cu(I) phenylacetylide providing β-lactams in yields of 45–85%. Substituents affect the reaction by either accelerating cycloaddition or minimizing side reactions.
