Title of article
Synthesis of 1-deoxy-l-gulonojirimycin and 1-deoxy-l-talonojirimycin
Author/Authors
Guaragna، نويسنده , , Annalisa and D’Alonzo، نويسنده , , Daniele and Paolella، نويسنده , , Concetta and Palumbo، نويسنده , , Giovanni، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
2045
To page
2047
Abstract
De novo synthesis of noncompetitive glycosidase inhibitors l-gulo-DNJ and l-talo-DNJ has been achieved in 9–10 steps starting from Garner’s aldehyde. Key to the success of this procedure was the construction of the 2,3-unsaturated piperidine 14, which syn dihydroxylation under Kishi’s and Donohoe’s conditions led to the desired iminosugars.
Keywords
Polyhydroxylated piperidines , dihydroxylation , Glycosidase inhibitors , l-Iminosugars
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1863385
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