Title of article
Direct microbial-catalyzed asymmetric α-hydroxylation of betulonic acid by Nocardia sp. NRRL 5646
Author/Authors
Qian، نويسنده , , Li-Wu and Zhang، نويسنده , , Jian and Liu، نويسنده , , Ji-Hua and Yu، نويسنده , , Bo-Yang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
2193
To page
2195
Abstract
Microbial transformation of betulonic acid by Nocardia sp. NRRL 5646 in preparative scale resulted in the isolation of one unexpected asymmetric α-hydroxylation product, methyl 2α-acetoxy-3-oxo-lup-20(29)-en-28-oate, and one known compound methyl 3-oxo-lup-20(29)-en-28-oate. The structures of metabolites were elucidated unambiguously by ESI-MS, 2D-NMR spectroscopy. This is the first successful microbial transformation of ketone α-hydroxylation of lupane-type pentacyclic triterpenes.
Keywords
biotransformation , Betulonic acid , Lupane-type pentacyclic triterpene , Ketone ?-hydroxylation , Nocardia sp. NRRL 5646
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1863503
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