Title of article :
Asymmetric synthesis of 3-hydroxyl-2-alkanones via tandem organocatalytic aminoxylation of aldehydes and chemoselective diazomethane homologation
Author/Authors :
Yang، نويسنده , , Li and Liu، نويسنده , , Run-Hua and Wang، نويسنده , , Xia-Bing and Weng، نويسنده , , Ling-Ling and Zheng، نويسنده , , Hu، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
Asymmetric synthesis of 3-hydroxyl-2-alkanones is achieved via one-pot, tandem organocatalytic aminoxylation of aldehydes and chemoselective CH2N2-induced homologation. Accelerating effect of water is observed in α-aminoxylation. MgCl2, a Lewis acid additive, improves the chemoselectivity of the diazomethane homologation to 6:1 in favor of ketone.
Keywords :
Rearrangements , diazo compounds , Oxygenations , organocatalysis , asymmetric synthesis
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
