Title of article
Efficient three-step sequence for the deamination of α-aminoesters. Application to the synthesis of CysLT1 antagonists
Author/Authors
Gonzلlez، نويسنده , , Alfredo and Pérez، نويسنده , , Daniel and Puig، نويسنده , , Carles and Ryder، نويسنده , , Hamish and Sanahuja، نويسنده , , Jordi and Solé، نويسنده , , Laia and Bach، نويسنده , , Jordi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
2750
To page
2753
Abstract
A practical and efficient three-step sequence for the deamination of α-aminoesters is reported. This method is based on the NaBH4-mediated selective reduction of α-diazoesters to α-hydrazonoesters and has been successfully applied to the deamination of several representative α-aminoesters including some l-cysteine ethyl ester derivatives, key intermediates in the synthesis of a series of CysLT1 antagonists.
Keywords
?-Hydrazonoesters , Reduction , ?-Aminoesters , ?-Diazoesters , deamination , CysLT1 antagonists
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1863921
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