Author/Authors :
Culf، نويسنده , , Adrian S. and Werner-Zwanziger، نويسنده , , Ulrike and Robertson، نويسنده , , Katherine N. and Chen، نويسنده , , Banghao and ?uperlovi?-Culf، نويسنده , , Miroslava and Barnett، نويسنده , , David A. and Ouellette، نويسنده , , Rodney J.، نويسنده ,
Abstract :
A novel approach to the synthesis of spirobicyclic Janovsky complexes is described. The complexes were prepared on silica and polystyrene polymeric supports as well as on a solution-borne poly(carbodiimide) polymer with 100% atom economy. A carbon-centered intramolecular de-aromatizing nucleophilic aromatic substitution ipso-cyclization mechanism describes the synthesis of these spirobicyclics. The molecules were characterized by solution and solid-state 1H and 13C NMR, IR, and MS.
Keywords :
Anionic sigma complex , Janovsky , Spirobicyclic , solid-phase synthesis , NMR
