Author/Authors :
Nakamura، نويسنده , , Tomoaki and Tsuboi، نويسنده , , Kazuma and Oshida، نويسنده , , Motoko and Nomura، نويسنده , , Tomoko and Nakazaki، نويسنده , , Atsuo and Kobayashi، نويسنده , , Susumu، نويسنده ,
Abstract :
First total synthesis of biologically active germacrane-type sesquiterpene (−)-diversifolin has been achieved. The features of the synthesis involve (i) ring-closing metathesis to give a 10-membered carbocycle, (ii) regioselective Mukaiyama aldol reaction of silyl dienol ether with formaldehyde at the α-position, and (iii) lactone transposition of the fully functionalized 11-oxabicyclo[6.2.1]undecane system.
Keywords :
Diversifolin , Lactone transposition , Germacrane-type sesquiterpenes , total synthesis , ring-closing metathesis
