Title of article :
A solid-phase total synthesis of the cyclic depsipeptide HDAC inhibitor spiruchostatin A
Author/Authors :
Iijima، نويسنده , , Yusuke and Munakata، نويسنده , , Asami and Shin-ya، نويسنده , , Kazuo and Ganesan، نويسنده , , A. M. Doi، نويسنده , , Takayuki and Takahashi، نويسنده , , Takashi، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
Spiruchostatin A, a potent histone deacetylase inhibitor, was efficiently synthesized from (3S,4R)-4-amino-3-hydroxy-5-methylhexanoic acid utilizing solid-phase peptide elongation with d-cysteine, d-alanine, and (E)-3-hydroxy-7-thio-4-heptenoic acid and solution-phase macrolactonization, followed by intramolecular disulfide formation.
Keywords :
natural product synthesis , Histone deacetylase , Cyclic depsipeptide , solid-phase synthesis
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
