Title of article
Highly efficient prolinamide-based organocatalysts for the direct asymmetric aldol reaction in brine
Author/Authors
Jia، نويسنده , , Ya-Ning and Wu، نويسنده , , Feng-Chun and Ma، نويسنده , , Xiao and Zhu، نويسنده , , Gong-Jian and Da، نويسنده , , Chao-Shan، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
3059
To page
3062
Abstract
Four prolinamide-based organocatalysts were readily synthesized and applied to the direct asymmetric aldol reactions of ketones and aromatic aldehydes in brine. When 2,4-dinitrophenol (DNP) was used as an acidic additive, 1 mol % low loading of 2b afforded aldol products with excellent diastereoselectivity of up to 98/2 dr and high enantioselectivity of up to 97% ee.
Keywords
direct aldol reaction , Asymmetric catalysis , Low loading of catalyst , brine , organocatalysis
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1864158
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