Title of article
Highly efficient asymmetric amination of β-keto esters catalyzed by chiral quaternary ammonium bromides
Author/Authors
Lan، نويسنده , , Quan and Wang، نويسنده , , Xisheng and He، نويسنده , , Rongjun and Ding، نويسنده , , Changhua and Maruoka، نويسنده , , Keiji، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
3280
To page
3282
Abstract
A highly efficient asymmetric amination of β-keto esters was achieved under phase transfer conditions using chiral quaternary ammonium bromide as a catalyst. The amination products were obtained in quantitative yields with up to 97% ee. One of the amination products represents a key intermediate for the preparation of aldose reductase inhibitor AS-3201.
Keywords
AS-3201 , Ammonium salt , Phase transfer catalysis , amination , ?-keto esters
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1864290
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