Title of article :
Total synthesis and determination of the absolute stereochemistry of the squalene synthase inhibitors CJ-13,981 and CJ-13,982
Author/Authors :
Calo، نويسنده , , Frederick and Bondke، نويسنده , , Alexander and Richardson، نويسنده , , Jeffery and White، نويسنده , , Andrew J.P and Barrett، نويسنده , , Anthony G.M.، نويسنده ,
Abstract :
The absolute and relative stereochemistries of the potent squalene synthase inhibitors CJ-13,981 and CJ-13,982 were determined to be 3S,4S by total synthesis of their antipodes using, as a key step, the diastereoselective alkylation of a chiral dioxolanone.
