Title of article
Reactivity of dearomatised furans synthesised via the decarboxylative Claisen rearrangement
Author/Authors
Camp، نويسنده , , Jason E. and Craig، نويسنده , , Donald، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
6
From page
3503
To page
3508
Abstract
The decarboxylative Claisen rearrangement (dCr) reaction of 1-(furan-2-yl)ethyl 2-tosylacetate afforded 2-ethylidene-3-(tosylmethyl)-2,3-dihydrofuran. Reaction of the dearomatised heterocycle with a variety of electrophiles gave addition products with excellent syn-diastereoselectivity. The furanol adducts were then utilised as functionalised scaffolds for a series of subsequent transformations.
Keywords
Claisen rearrangement , Microwave-assisted synthesis , Polysubstituted furan , Heteroaromatic , aldol
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1864469
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