An efficient synthesis of base-substituted analogues of S-adenosyl-dl-homocysteine

An efficient method for the preparation of base-substituted S-adenosyl-dl-homocysteine analogues as well as of 2-chloro-N6-alkylated S-adenosyl-dl-homocysteine analogues is described. The method uses a convergent strategy that employs a common intermediate late in the overall synthesis and allows small libraries of SAH analogues to be prepared in a relatively short period of time.