Author/Authors :
Kaila، نويسنده , , Jitendra C. and Baraiya، نويسنده , , Arshi B. and Pandya، نويسنده , , Amit N. and Jalani، نويسنده , , Hitesh B. and Vasu، نويسنده , , Kamala K. and Sudarsanam، نويسنده , , V.، نويسنده ,
Abstract :
Convenient synthesis of 2-amino-1,5-disubstituted and 2-amino-1,4,5-trisubstituted imidazoles has been reported using readily available starting materials and simple reagents under mild conditions. Guanylation of 1-amidino-3-trityl-thioureas 1 and 7 using mercury(II) chloride (Caution) as a thiophile resulted in corresponding guanidines 2 and 8 which on reaction with α-bromo ketones yielded 2-tritylaminoimidazoles. Deprotection of 2-tritylaminoimidazoles using trifluoroacetic acid at room temperature furnished desired 2-aminoimidazoles 4 and 10 in good to moderate yields.
Keywords :
Guanidines , 2-Aminoimidazoles , Amidinothioureas , Thiophile
