Title of article :
Preparation of proximal β-hydroxy silyl enol ethers from α,β-epoxyketones using silyllithium reagents
Author/Authors :
Baker، نويسنده , , Heather K. and Hartel، نويسنده , , Aaron M.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
A new method for the stereoselective preparation of proximal β-hydroxy silyl enol ethers from α,β-epoxyketones using silyllithium reagents has been developed. The reaction is believed to proceed via Brook rearrangement assisted by opening of the adjacent epoxide. A number of α,β-epoxyketones were reacted with methyldiphenylsilyllithium to form the corresponding proximal β-hydroxy silyl enol ethers in good to excellent yield and excellent stereoselectivity.
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters