Title of article
Highly stereoselective synthesis of steroidal 2,5-diketopiperazines based on isocyanide chemistry
Author/Authors
Bruttomesso، نويسنده , , Andrea C. and Eiras، نويسنده , , Javier and Ramيrez-Salgado، نويسنده , , Javier A. and Galagovsky، نويسنده , , Lydia R.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
4022
To page
4024
Abstract
In this Letter we report that the Ugi reaction/cyclization sequence on a steroidal 17-carboxaldehyde leads to novel steroidal 2,5-diketopiperazines with a noteworthy stereoselectivity. A wide variety in the substitution pattern in the heterocyclic moiety was easily achieved by changing the components in the Ugi reaction.
Keywords
Ugi reaction , multicomponent reaction , 2 , 5-Diketopiperazines , Heterocyclic steroids
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1864841
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