Title of article :
An expeditious synthesis of cyanohydrin trimethylsilyl ethers using tetraethylammonium 2-(carbamoyl)benzoate as a bifunctional organocatalyst
Author/Authors :
Dekamin، نويسنده , , Mohammad G. and Sagheb-Asl، نويسنده , , Solmaz and Reza Naimi-Jamal، نويسنده , , M.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Pages :
4
From page :
4063
To page :
4066
Abstract :
Phthalimide and tetraethylammonium hydroxide react via an unusual pathway to afford tetraethylammonium 2-(carbamoyl)benzoate (TEACB) which is of interest as a bifunctional organocatalyst. TEACB (0.5 mol %) was found to catalyze the addition of trimethylsilyl cyanide (TMSCN) to carbonyl compounds under solvent-free conditions at room temperature with very short reaction times. A wide variety of aldehydes and ketones were transformed into the corresponding cyanohydrin trimethylsilyl ethers in high to quantitative yields.
Keywords :
Tetraethylammonium 2-(carbamoyl)benzoate , Bifunctional organocatalysis , cyanohydrins , carbonyl compounds , Cyanosilylation
Journal title :
Tetrahedron Letters
Serial Year :
2009
Journal title :
Tetrahedron Letters
Record number :
1864876
Link To Document :
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