Title of article
Synthesis of new ribosylated Asn building blocks as useful tools for glycopeptide and glycoprotein synthesis
Author/Authors
Bonache، نويسنده , , M. Angeles and Nuti، نويسنده , , Francesca and Le Chevalier Isaad، نويسنده , , Alexandra and Real-Fernلndez، نويسنده , , Feliciana and Chelli، نويسنده , , Mario and Rovero، نويسنده , , Paolo and Papini، نويسنده , , Anna M.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
4151
To page
4153
Abstract
We performed the first synthesis of new Asn derivatives bearing α- or β-ribose as pure anomers, linked by an N-glycosidic bond, on the side chain of the Asn residue orthogonally protected for Fmoc/tBu SPPS, by an efficient five-step strategy with a global yield of 73% starting from d-ribose. These building blocks are obtained in a large scale and can be useful tools for glycopeptide and glycoproteins synthesis.
Keywords
N-Glycosylated Asn for SPGPS , ?- and ?-ribofuranose Asn , Triazine-based coupling reagent
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1864945
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