Title of article
Efficient synthesis of bongkrekic acid. Three-component convergent strategy
Author/Authors
Sato، نويسنده , , Yukiko and Aso، نويسنده , , Yoshifumi and Shindo، نويسنده , , Mitsuru، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
4164
To page
4166
Abstract
An efficient total synthesis of the apoptosis inhibitor bongkrekic acid was accomplished using a three-component convergent strategy involving a Kocienski-Julia olefination and a Suzuki–Miyaura coupling, in which the longest linear sequence was 18 steps and proceeded in 6.4% overall yield. The torquoselective olefination also contributed to the shortening of the synthesis.
Keywords
Apoptosis inhibitor , total synthesis , Kocienski-Julia olefination , Suzuki–Miyaura coupling , natural product , Torquoselective olefination , Ynolates
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1864958
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