Title of article
Enantioselective catalytic addition of nitroesters to N-carboalkyloxy imines: a route to quaternary stereocenters
Author/Authors
Puglisi، نويسنده , , Alessandra and Raimondi، نويسنده , , Laura and Benaglia، نويسنده , , Maurizio and Bonsignore، نويسنده , , Martina and Rossi، نويسنده , , Sergio، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
4340
To page
4342
Abstract
A readily available, low cost bifunctional organic catalyst promoted the addition of nitroesters to imines; in the reaction between 2-nitropropionates and N-Boc protected aldehyde-imines the product bearing a new quaternary stereocenter was obtained in up to 81% ee. The positively charged catalyst was postulated to control the attack of the enolic form of nitroester to imine through a hydrogen bonding network.
Keywords
Nitroesters , Catalysis , Quaternary stereocenter , Bifuctional catalyst , Synthetic methods
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1865091
Link To Document