Title of article :
A concise synthesis of indolic enamides: coscinamide A, coscinamide B, and igzamide
Author/Authors :
Ma، نويسنده , , Yuelong and Yakushijin، نويسنده , , Kenichi and Miyake، نويسنده , , Fumiko and Horne، نويسنده , , David، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
A concise synthesis of indolic enamides coscinamide A, coscinamide B, and the brominated tryptamine derivative igzamide is described. Both E- and Z-isomers of these natural compounds were obtained during the thermally assisted dehydration reaction and were tested for antitumor activity. Coscinamide B was found to possess antitumor activity against DU145 with an IC50 of 7.6 μg/mL.
Keywords :
Indolic enamide , Coscinamide B , Coscinamide A , Igzamide , Dehydration reaction
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
