Thiol addition to t-butyl methyl squarate. Efficient synthesis of novel sulfur-linked squaryl group-containing glutamate analogs
Author/Authors :
Shinada، نويسنده , , Tetsuro and Yamasaki، نويسنده , , Atsuko and Kiniwa، نويسنده , , Yu-ichi and Shimamoto، نويسنده , , Keiko and Ohfune، نويسنده , , Yasufumi، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Pages :
4
From page :
4354
To page :
4357
Abstract :
Novel sulfur-linked squaryl group-containing glutamate analogs were synthesized via addition and mono-substitution reactions of thiols to t-butyl methyl squarate (BMSQ: 7) in two steps. A glutamate analog prepared from Boc-l-Cys showed a potent binding affinity to KA/AMPA receptors.
