Title of article
First chemoenzymatic synthesis of immunomodulating macrolactam pimecrolimus
Author/Authors
Ferraboschi، نويسنده , , Patrizia and Colombo، نويسنده , , Diego and De Mieri، نويسنده , , Maria and Grisenti، نويسنده , , Paride، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
5
From page
4384
To page
4388
Abstract
The preparation of pimecrolimus, a synthetic derivative of ascomycin endowed with immunomodulatory activity, requires the selective protection of 24-hydroxy group of the ascomycin, before elaboration of the 32-hydroxy group. The aim was achieved by means of two regioselective Candida antarctica lipase-catalyzed steps. The structure of the new key intermediates, 24-, 32-monoacetates, and 24,32-diacetate, was established by means of an unambiguous NMR study.
Keywords
Immunomodulator , macrolactam , Ascomycin , Lipase , regioselectivity
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1865126
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