Title of article
Synthesis of biotinylated sialoside to probe CD22–ligand interactions
Author/Authors
Abduallah، Ejaz نويسنده School of Business and Economics Abduallah, Ejaz , Hajjaj H.M. and Watanabe، نويسنده , , Kozo and Hayashizaki، نويسنده , , Koji and Iwayama، نويسنده , , Yuki and Takematsu، نويسنده , , Hiromu and Kozutsumi، نويسنده , , Yasunori and Tsubata، نويسنده , , Takeshi and Ishida، نويسنده , , Hideharu and Kiso، نويسنده , , Makoto، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
4488
To page
4491
Abstract
Biotin conjugate of the most potent ligand for mouse CD22 was designed and synthesized. The key synthetic step involved the dual capability of Hanessian reaction for debenzylation and simultaneous conversion of the anomeric p-methoxyphenyl group into the corresponding phenylthioglycoside in one step. Competition enzyme-linked immunosorbent assay (ELISA) for testing the binding affinity of synthetic sialosides was developed based on this biotinylated ligand.
Keywords
Biotinylated CD22 ligand , click chemistry , Hanessian reaction
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1865206
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